Breast cancer alone kills some 458,000 people each year, according to the World Health Organization, mainly in low- and middle-income countries. It has got to be a priority to ensure that more women can access gene testing and lifesaving preventive treatment, whatever their means and background, wherever they live.

I became an actress because my mom wanted me to become an actress. It took me until my mid-30s to realize I actually didn’t. I actually wanted to write and direct and be more involved in politics and humanitarian issues.

I think if you've never been pregnant, you can over play pregnant and you can do a lot of different things with pregnant.

Once you have six children, you're committed.

Our family may seem extraordinary in some magazines or something, but at home it's not. We're really just a very loving family. We're very close, and we don't read magazines. We just kind of go to work and come home. We try to keep a sense of reality into their lives. What's truly real, not Hollywood real.

As a director, I hoped that I was able to help the actors by giving them the space and the respect they need and the trust. I gave them what I always felt I needed when I was working.

On second marriage: It took me by surprise, too, because overnight, we totally changed. I think one day we had just nothing in common. And it's scary but I think it can happen when you get involved and you don't know yourself yet.