We have such a terrible, terrible misconception of science. We think it involves the definite, the precise, the known; it is a horrid series of gates to an unknown as vast of the universe; which means endless.

It was as if this night were only one of thousands of nights, world without end, night curving into night to make a great arching line of which I couldn’t see the end, a night in which I roamed alone under cold, mindless stars.

The most difficult novel I have had to write in terms of just getting it done was The Vampire Lestat. It took a year to write.

When you find out there is no ultimate good and evil in which you can place your faith, the world does not fall apart at the seams. It simply means that every decision is more difficult, more critical, because you are creating the good and evil yourself and they are very real.

How can so much beauty hide such a bruised and steely heart, and why must I love him, why must I lean in my weariness upon his irresistible yet indomitable strength? Is he not the wizend funeral spirit of a dead man in a child's clothes?

Protect your voice and your vision. If going on the Internet and reading Internet reviews is bad for you, don’t do it. … Do what gets you to write and not what blocks you. … Don’t take any guff off anybody.

But during all these years I had a vague but persistent desire to return to New Orleans. I never forgot New Orleans. And when we were in tropical places and places of those flowers and trees that grow in Louisiana, I would think of it acutely and I would feel for my home the only glimmer of desire I felt for anything outside my endless pursuit of art.