David Fincher is a longtime friend. As a director, my wife had worked with him as a makeup artist when he would do Madonna videos years before, and his child and my oldest child were in preschool together, so we're kind of dad-friends through that, too.

'ER' was so huge that whatever I did coming back to television, I'd have to feel as strongly about.

People relate to things that feel real to them. All the good, happy, over-sexed and moneyed endings on TV are not the way most of us feel in our lives. The success of 'E.R.,' I think, is not relying on overly sentimental stories that are solved where people's lives wrap up nicely with happy endings.

I didn't start jogging or running until I was 37 years old. It was something that really helped me change my life.

I was always enjoying the moment. Acting, writing, looking for roles and getting involved with people and trying to create something that would be entertaining to people. With 'E.R.,' we were all very lucky to get this combination of people together in the right story in the right way to take it to the level it has reached.

My family had all kinds of complications in relationships. I would like to meet the person who did not. Since when is being absolutely perfect what being a human is? What do we gain from that?

Be what you are. Don't change yourself for anything. God made you that way for a reason.