David Fincher is a longtime friend. As a director, my wife had worked with him as a makeup artist when he would do Madonna videos years before, and his child and my oldest child were in preschool together, so we're kind of dad-friends through that, too.

To think one film makes a career is ridiculous. It's important to keep perspective and do things other than for money.

I didn't start jogging or running until I was 37 years old. It was something that really helped me change my life.

'ER' was so huge that whatever I did coming back to television, I'd have to feel as strongly about.

You know, you never say never because before I did 'ER,' I always said 'I'll never do a TV series,' so that's what I said.

People relate to things that feel real to them. All the good, happy, over-sexed and moneyed endings on TV are not the way most of us feel in our lives. The success of 'E.R.,' I think, is not relying on overly sentimental stories that are solved where people's lives wrap up nicely with happy endings.

I did tons of theater in school, and then when I was 16 and got my driver's license, I started driving to Los Angeles, along with my friend Eric Stoltz, who was a year ahead of me and was doing the same thing. So we had the same manager, and we started auditioning for things and doing commercials when we were 16.