Depend upon it there comes a time when for every addition of knowledge you forget something that you knew before. It is of the highest importance, therefore, not to have useless facts elbowing out the useful ones.

...Holmes, who loathed every form of society with his whole Bohemian soul, remained in our lodgings in Baker Street, buried among his old books, and alternating from week to week between cocaine and ambition, the drowsiness of the drug, and the fierce energy of his own keen nature.

He had never seen a woman doctor before, and his whole conservative soul rose up in revolt at the idea. He could not recall any biblical injunction that the man should remain ever the doctor and the woman the nurse, and yet he felt as if a blasphemy had been committed.

I should dearly love that the world should be ever so little better for my presence. Even on this small stage we have our two sides, and something might be done by throwing all one's weight on the scale of breadth, tolerance, charity, temperance, peace, and kindliness to man and beast. We can't all strike very big blows, and even the little ones count for something.

Still, it is an error to argue in front of your data. You find yourself insensibly twisting them round to fit your theories.

If I had never touched Holmes, who has tended to obscure my higher work, my position in literature would at the present moment be a more commanding one.

It is not really difficult to construct a series of inferences, each dependent upon its predecessor and each simple in itself. If, after doing so, one simply knocks out all the central inferences and presents one's audience with the starting-point and the conclusion, one may produce a startling, though perhaps a meretricious, effect.