I was shooting a scene in my new film, No Strings Attached, in which I say to Natalie Portman, “If you miss me. you can’t text, you can’t email, you can’t post it on my Facebook wall. If you really miss me, you come and see me.

I wanted to be a genetic engineer. That was my goal in college. I wanted to figure out what the codon sequence was that causes replication in a cardio myopathic virus. That was my goal.

The thing that enchants me the most is the ability women have to feel other people's pain. The total empathy that women have is extraordinary.

I feel like a fraud... My name is not even actually Ashton. Ashton is my middle name.

Vulnerability is the essence of romance. It's the art of being uncalculated, the willingness to look foolish, the courage to say, 'This is me, and I'm interested in you enough to show you my flaws with the hope that you may embrace me for all that I am but, more important, all that I am not.'

I can't grow a mustache. It's pretty sad if I attempt to.

I live my life like anybody else, and people choose to write about mine. And what they write I can't control - when they write lies at least - because the laws can't really protect you unless you can prove malicious intent. So I just choose not to read it.