Boston is a tough and resilient town. So are its people. I'm supremely confident that Bostonians will pull together, take care of each other, and move forward as one proud city. And as they do, the American people will be with them every single step of the way.

Don’t ever let anybody tell you that your efforts don’t matter or that your voice doesn’t count. Don’t ever believe that you can’t make a difference. You have.

My job is to communicate to the American people that the Muslim world is filled with extraordinary people who simply want to live their lives and see their children live better lives. My job to the Muslim world is to communicate that the Americans are not your enemy. We sometimes make mistakes. But if you look at the track record America was not born as a colonial power, and that the same respect and partnership that America had with the Muslim world as recently as 20 or 30 years ago, there's no reason why we can't restore that. And that I think is going to be an important task.

Shooting in Orlando is a sobering reminder that attacks on any American, regardless of race, ethnicity, religion or sexual orientation, is an attack on all of us and on the fundamental values of equality and dignity that define us as a country. And no act of hate or terror will ever change who we are or the values that make us Americans.

If condoms and potentially microbicides can prevent millions of deaths [from AIDS], they should be made more widely available. I know that there are those who, out of sincere religious conviction, oppose such measures. And with these folks, I must respectfully but unequivocally disagree.

So don't get cynical. Cynicism didn't put a man on the moon. Cynicism has never won a war, or cured a disease, or built a business, or fed a young mind. Cynicism is a choice. And hope will always be a better choice.

Yes, our greatness as a nation has depended on individual initiative, on a belief in the free market. But it has also depended on our sense of mutual regard for each other, of mutual responsibility. The idea that everybody has a stake in the country, that we're all in it together and everybody's got a shot at opportunity. Americans know this. We know that government can't solve all our problems - and we don't want it to. But we also know that there are some things we can't do on our own. We know that there are some things we do better together.