The alternative, no limits on Iran's nuclear program, no inspections, an Iran that's closer to a nuclear weapon, the risk of regional nuclear arms race, and the greater risk of war - all that would endanger our [American] security.

When we think of the major threats to our national security, the first to come to mind are nuclear proliferation, rogue states and global terrorism. But another kind of threat lurks beyond our shores, one from nature, not humans - an avian flu pandemic.

Do I wish that things were more orderly in Washington and rational and people listened to the best arguments and compromised and operated in a more thoughtful and organized fashion? Absolutely. But when you look at history that's been the exception rather than the norm.

The Asia Pacific is home to nearly half the world's population, a growing middle class and holds so much opportunity for us all.

Under my plan of a cap-and-trade system, electricity rates would necessarily skyrocket.

We've evolved a lot since 9/11 also, in terms of our law enforcement capabilities, our intelligence capabilities, military, counterterrorism.

We don't quit. I don't quit. Let's seize this moment.