I really enjoy going to a library and spending the day doing research - to me that is the most pleasurable part of writing the science book.

As James Surowiecki noted in a New Yorker article, given a choice between developing antibiotics that people will take every day for two weeks and antidepressants that people will take every day for ever, drug companies not surprisingly opt for the latter. Although a few antibiotics have been toughened up a bit, the pharmaceutical industry hasn't given us an entirely new antibiotic since the 1970s.

Traveling is more fun - hell, life is more fun - if you can treat it as a series of impulses.

Every twenty minutes on the Appalachian Trail, Katz and I walked farther than the average American walks in a week. For 93 percent of all trips outside the home, for whatever distance or whatever purpose, Americans now get in a car. On average the total walking of an American these days - that's walking of all types: from car to office, from office to car, around the supermarket and shopping malls - adds up to 1.4 miles a week, barely 350 yards a day.

When the Duke [W.J.C. Scott-Bentinck] died, his heirs found all of the aboveground rooms devoid of furnishings except for one chamber in the middle of which sat the Duke's commode. The main hall was mysteriously floor less. Most of the rooms were painted pink. The one upstairs room in which the Duke had resided was packed to the ceiling with hundreds of green boxes, each of which contained a single dark brown wig. This was, in short, a man worth getting to know.

For anyone of a rational disposition, fashion is often nearly impossible to fathom. Throughout many periods of history – perhaps most – it can seem as if the whole impulse of fashion has been to look maximally ridiculous. If one could be maximally uncomfortable as well, the triumph was all the greater.

It is a curious feature of our existance that we come from a planet that is very good at promoting life but even better at extinguishing it.