My guideline has always been to avoid a focus on me personally. Not because of any deep, dark secrets. Rather just a sense of privacy.

As I see it, there are two great forces of human nature: self-interest, and caring for others. Capitalism harnesses self-interest in a helpful and sustainable way, but only on behalf of those who can pay. Government aid and philanthropy channel our caring for those who can't pay. But to provide rapid improvement for the poor we need a system that draws in innovators and businesses in a far better way than we do today.

There certainly is a case to be made that taxes should be more progressive.

Every three years, we have to go to the governments and say, okay, you know you're saving millions of lives and even though your budgets are tight, helping Africa avoid this disaster really is a priority.

Even for the diseases we don't focus on, cancer, heart disease, you're going to be way better off being sick 10 years from now than any time in the past.

With tech companies, whoever's the leader is always questioned, you know. They say, 'Is this the end of them?' And - there's more - more times people think that's the case than it really is the case.

There's a true schizophrenia where if you say to voters, you know, do you think the federal government spends too much money and they should spend less, they say yeah, absolutely. Then you name specific things, like Pell grants for students and they say, no, not that. How 'bout NIH, medical research funding? Nah, you really shouldn't cut that. And pretty soon you've proved that what the American public is against is arithmetic.