[Melinda Gates] is a lot of fun to work with. There's some of the people skills that she's better at and cares about more. It'd be a mistake not to think of her as very numerical and interested in the science. I enjoy, if I get ahead of her, say, understanding the immune system, then we can spend a few hours, where I'm going through how amazing it is and interesting, and how that affects our creating new products, so I've always had a partner.

What destroys more self-confidence than any other educational thing in America is being assigned to some remedial math when you get into some college, and then it's not taught very well and you end up with this sense of, 'Hey, I can't really figure those things out.'

Patience is a key element of success.

When you have a product that has zero sales, it is easy for people to say whatever they want about it and almost fantasize about it.

(Talking about his first computer) Like all kids we not only fooled around with our toys, we changed them. If you've ever watched a child with a cardboard carton and a box of crayons create a spaceship with cool control panels, or listened to their improvised rules, such as "Red cars can jump all others," then you know that this impulse to make a toy do more is at the heart of innovative childhood play. It is also the essence of creativity.

... No one is less happy than I am with the performance of Microsoft stock! I've lost tens of billions of dollars this year - if you check, you'll see that's more than most people make in a lifetime!

Microsoft's only factory asset is the human imagination.