Since when has the world of computer software design been about what people want? This is a simple question of evolution. The day is quickly coming when every knee will bow down to a silicon fist, and you will all beg your binary gods for mercy.

When you are failing, you are forced to be creative, to dig deep and think, night and day.

The belief that the world is getting worse, that we can't solve extreme poverty and disease, isn't just mistaken. It is harmful.

Anything you do, you better enjoy it for its value. Because people are going to second-guess everything you do.

Energy is very primal stuff and there are a lot of leads that are promising, still at a fairly risky stage, but over the next decade some of these breakthrough approaches are going to pay out, and U.S. research and U.S. leadership on this should be part of how it gets solved.

Well the Global Fund, because of how well it's worked on not only AIDS, but also malaria and tuberculosis, I'd say it's well accepted. I mean, it's not politically controversial that this is a great humanitarian effort. But budgets are very very tight.

The way to be successful in the software world is to come up with breakthrough software, and so whether it's Microsoft Office or Windows, its pushing that forward. New ideas, surprising the marketplace, so good engineering and good business are one in the same.