Even in some of our vaccine areas, like an AIDS vaccine, things have taken longer than we expected, but we have the pipeline of tools. The biological information that we have that gives us insights is fantastic.

If you go back to 1800, everybody was poor. I mean everybody. The Industrial Revolution kicked in, and a lot of countries benefited, but by no means everyone.

In a system of capitalism, as people's wealth rises, the financial incentive to serve them rises. As their wealth falls, the financial incentive to serve them falls, until it becomes zero. We have to find a way to make the aspects of capitalism that serve wealthier people serve poorer people as well.

I believe it’s not only possible to eradicate malaria; I believe it’s necessary. Ultimately, the cost of controlling it endlessly is not sustainable. The only way to stop this disease is to end it forever.

Depending on how quickly you get ocean rise, you have people who live in river deltas [at risk]. Bangladesh is largely a river delta, and the rising sea level means that when storms come in, the human sanitation is backing up, the ability to farm, it's destructive-type situations like you saw in New Orleans with Katrina. You're increasing the frequency of that stuff in low-lying areas fairly dramatically.

I'm sorry that we have to have a Washington presence. We thrived during our first 16 years without any of this. I never made a political visit to Washington and we had no people here. It wasn't on our radar screen. We were just making great software.

Of my mental cycles, I devote maybe 10 percent to business thinking. Business isn't that complicated. I wouldn't want to put it on my business card.