Who in their right mind would ever need more than 640k of ram!?

For all these infectious diseases, the goal is to eventually get rid of them. And to do that we need to invent new tools, but nobody was doing that because there was no money to buy on behalf of the poorest, even the existing tools.

Our current expectations for what our students should learn in school were set fifty years ago to meet the needs of an economy based on manufacturing and agriculture. We now have an economy based on knowledge and technology.

When AIDS emergency broke out and was killing millions in Africa, the Global Fund was created so that a level of generosity would show up and buy the medicines to save those lives.

Like my friend Warren Buffett, I feel particularly lucky to do something every day that I love to do. He calls it "tap dancing to work."

Philanthropy should be taking much bigger risks that business. If these are easy problems, business and government can come in and solve them.

Great organizations demand a high level of commitment by the people involved. Eliminate politics, by giving everybody the same message. Keep a flat organization in which all issues are discussed openly. Empower teams to do their own things.