The way to be successful in the software world is to come up with breakthrough software, and so whether it's Microsoft Office or Windows, its pushing that forward. New ideas, surprising the marketplace, so good engineering and good business are one in the same.

Anyone who spends their life on a computer is pretty unusual.

But the improvements will happen faster and last longer if we can channel market forces, including innovation that's tailored to the needs of the poorest, to complement what governments and nonprofits do. We need a system that draws in innovators and businesses in a far better way than we do today.

If you withdraw the incredible focus on polio, it will spread back, and in poor countries you'll get something like 100,000 cases a year. So by being very intense and getting the cases down to zero, what you do is you avoid all the future cases.

The only big companies that succeed will be those that obsolete their own products before somebody else does.

Climate change is a terrible problem, and it absolutely needs to be solved. It deserves to be a huge priority.

The flatter the corporate hierarchy, the more likely it is that employees will communicate bad news and act upon it.