Like my friend Warren Buffett, I feel particularly lucky to do something every day that I love to do. He calls it "tap dancing to work."

If somebody is working on a new medicine, computer science helps us model those things. We have a whole group here in Seattle called the Institute for Disease Modelling that is a mix of computer science and math-type people, and the progress we're making in polio or plans for malaria or really driven by their deep insights.

When you lose a customer, it can be tempting to tell each other, "That customer's not very sharp. They just made the wrong decision".

Software is more important than hardware.

The moral systems of religion, I think, are super important.

SPAM is taking e-mail, which is a wonderful tool, and exploiting the idea that it's very inexpensive to send mail.

If GM had kept up with technology like the computer industry has, we would all be driving $25 cars that got 1,000 MPG.