The barrier to change is not too little caring; it is too much complexity. To turn caring into action, we need to see a problem, see a solution, and see the impact. But complexity blocks all three steps.

People are using Windows PCs more than they watch TV now.

Great organizations demand a high level of commitment by the people involved. Eliminate politics, by giving everybody the same message. Keep a flat organization in which all issues are discussed openly. Empower teams to do their own things.

Cutting through complexity to find a solution runs through four predictable stages: determine a goal, find the highest-leverage approach, discover the ideal technology for that approach, and in the meantime, make the smartest application of the technology that you already have - whether it's something sophisticated, like a drug, or something simpler, like a bednet.

[Africa] is the one continent where you still have a lot more young people than old people. So making sure they're healthy, good nutrition, good education. That'll be important for the world.

Anything that someone's interested in should be very, very easy to call up onto the screen. And in fact the computer over time will see what you're interested in and make that immediately available without your having to be give any commands at all.

If you're smart, you often want a feedback loop so you know if what you've done is... is right.