If somebody is considering being willing to go out and work in the field in global health, those are a particular class of heroes because it's hard to work in those places. Our foundation gets so many of our learnings from people who've been out there and seen, "this tool is not going to work there, there's more of a problem here than you know." You should really get involved in that.

If your goal is to make the world a better place, one thing you can do is pick a specific challenge that you really care about. Then, learn as much as you can about it and try to volunteer your time to help an organization that is working in this area. While you're doing that, look for creative new ways to use technology to tackle parts of the problem that you come in contact with.

You’ve got to give great tools to small teams. Pick good people, use small teams and give them great tools so that they are very productive in terms of what they are doing.

The PC has improved the world in just about every area you can think of. Amazing developments in communications, collaboration and efficiencies. New kinds of entertainment and social media. Access to information and the ability to give a voice people who would never have been heard.

Until we're educating every kid in a fantastic way, until every inner city is cleaned up, there is no shortage of things to do.

When you lose a customer, it can be tempting to tell each other, "That customer's not very sharp. They just made the wrong decision".

Government investment unlocks a huge amount of private sector activity, but the basic research that we put into IT work that led to the Internet and lots of great companies and jobs, the basic work we put into the health care sector, where it's over $30 billion a year in R&D that led the biotech and pharma jobs. And it creates jobs and it creates new technologies that will be productized. But the government has to prime the pump here. The basic ideas, as in those other industries, start with government investment.