There's no magic line between an application and an operating system that some bureaucrat in Washington should draw.

I don't have a magic formula for prioritizing the world's problems.

Innovation is moving at a scarily fast pace.

I don't have any TVs with their over-the-air receivers connected in my house. But when I'm in a hotel room or other places that have a TV, then I turn it on and flip the channels just like everybody else. I'm not immune to the lures of television. I just try to stay away from it because I like to read.

I'm cooler than you. WAAAY cooler.

Cutting through complexity to find a solution runs through four predictable stages: determine a goal, find the highest-leverage approach, discover the ideal technology for that approach, and in the meantime, make the smartest application of the technology that you already have - whether it's something sophisticated, like a drug, or something simpler, like a bednet.

There's a true schizophrenia where if you say to voters, you know, do you think the federal government spends too much money and they should spend less, they say yeah, absolutely. Then you name specific things, like Pell grants for students and they say, no, not that. How 'bout NIH, medical research funding? Nah, you really shouldn't cut that. And pretty soon you've proved that what the American public is against is arithmetic.