We're still missing about a dozen vaccines that will make a huge difference. For adults, we've got HIV and TB are still huge; for kids malaria is still killing a half million kids a year out of that 6 million. We probably need some vaccines, but we need a little more data to make sure we're getting the vaccines that will save the most lives.

Bringing together the right information with the right people will dramatically improve a company's ability to develop and act on strategic business opportunities.

We have completely eradicated smallpox; we have almost eradicated polio. That's the miracle of vaccines, which is even greater than that of antibiotics.

I have a company that is not Microsoft, called Corbis. Corbis is the operation that merged with Bettman Archives. It has nothing to do with Microsoft. It was intentionally done outside of Microsoft because Microsoft isn't interested.

We really have to work hard to remind people even though this is far away, that's it's probably the most generous thing governments have ever come together to do. Since World War II, this new institution is the only one that's emerged and is saving all these lives.

If your goal is to make the world a better place, one thing you can do is pick a specific challenge that you really care about. Then, learn as much as you can about it and try to volunteer your time to help an organization that is working in this area. While you're doing that, look for creative new ways to use technology to tackle parts of the problem that you come in contact with.

You may have heard of Black Friday and Cyber Monday. There's another day you might want to know about: Giving Tuesday. The idea is pretty straightforward. On the Tuesday after Thanksgiving, shoppers take a break from their gift-buying and donate what they can to charity.