We're still missing about a dozen vaccines that will make a huge difference. For adults, we've got HIV and TB are still huge; for kids malaria is still killing a half million kids a year out of that 6 million. We probably need some vaccines, but we need a little more data to make sure we're getting the vaccines that will save the most lives.

Computer science … jobs should be way more interesting than even going to Wall Street or being a lawyer--or, I can argue, than anything but perhaps biology, and there it's just a tie.

By 2035, there will be almost no poor countries left in the world.

A breakthrough in machine learning would be worth ten Microsofts.

I think there certainly was a milestone in the '90s with regards to the Internet achieving critical mass. There were several magical factors that came together: the creation of HTML by Tim Berners-Lee, the drop in the price of communications, and all the PCs out there that you could put this software into.

When you have a product that has zero sales, it is easy for people to say whatever they want about it and almost fantasize about it.

You know, development sometimes is viewed as a project in which you give people things and nothing much happens, which is perfectly valid, but if you just focus on that, then you'd also have to say that venture capital is pretty stupid, too. Its hit rate is pathetic. But occasionally, you get successes, you fund a Google or something, and suddenly venture capital is vaunted as the most amazing field of all time. Our hit rate in development is better than theirs, but we should strive to make it better.