The ideal thing would be to have a 100 percent effective AIDS vaccine. And to have broad usage of that vaccine. That would literally break the epidemic.

If you’re a person struggling to eat and stay healthy you might have heard about Michael Jordan or Muhammad Ali, but you’ll never have heard of Bill Gates.

The nuclear approach I'm involved in is called a traveling-wave reactor, which uses waste uranium for fuel. There's a lot of things that have to go right for that dream to come true - many decades of building demo plants, proving the economics are right. But if it does, you could have cheaper energy with no CO2 emissions.

It's easier for our software to compete with Linux when there's piracy than when there's not.

I regret being the richest man in the world because that position attracts undeserved publicity.

The intersection of law, politics, and technology is going to force a lot of good thinking.

I didn't used to wear a watch. Now I have a SPOT watch, which I wear all the time.