Although I don't have a prescription for what others should do, I know I have been very fortunate and feel a responsibility to give back to society in a very significant way.

It's pretty incredible to look back 30 years to when Microsoft was starting and realize how work has been transformed. We're finally getting close to what I call the digital workstyle.

We are always saying to ourself.. we have to innovate. We got to come up with that breakthrough... we're only paid for breakthroughs.

With nuclear weapons, you'd think you would probably stop after killing 100million. Smallpox won't stop. Because the population is naïve, and there are no real preparations. That, if it got out and spread, would be a larger number.

Effective philanthropy requires a lot of time and creativity - the same kind of focus and skills that building a business requires.

The world is not flat, and PCs are not, in the hierarchy of human needs, in the first five rungs.

There are several hundred people who stayed in the Ebola-affected countries and continued to do the work, put themselves at great risk because medical workers are the most likely to be infected because they're helping out when the person's health is deteriorating, including quite a bit of bleeding as they're getting very, very sick.