When you think about email or IMing, why aren't you writing back? I can see your avatar, I know you're online, why aren't you writing me back? But with Twitter, everybody sends their responses to Twitter, and Twitter then sends them out to everyone. So there's not this constant connection. You can be hyperconnected, then you can take a break for a couple days and it's fine.

Embrace your constraints.

Both my wife and I have a lot of compassion for animals in general.

The two things I use the most are the MacBook Air and my iPhone. Those are my two most-used gadgets that are dented, scratched and smashed.

A personal belief is that if you're not personally invested in what you're working on, you'll fail.

This idea that the open exchange of information can have a positive global impact is being proven over and over again around the world nearly on a daily basis - and for Secretary Clinton to recognize that, I think, is a huge step.

We did Twitter, and Twitter grew so fast, and in 2006 we spun it out into Twitter, Inc.