Much of the early work focused on dopamine and we were really looking for rewarding sorts of effects and sure enough, we only found that. But you can destroy the main dopamine-producing structures of the brain and you can still get an animal to self-administer drugs like cocaine.

The policy that received more attention particularly in the past decade and a half or so has been the US cocaine policy, the differential treatment of crack versus powder cocaine and question is how my research impacted my view on policy. Clearly that policy is not based on the weight of the scientific evidence. That is when the policy was implemented, the concern about crack cocaine was so great that something had to be done and congress acted in the only way they knew how, they passed policy and that's what a responsible society should do.

I think about my cocaine use. I liked it. I thought it was a great drug. But I knew that if I was doing that almost exclusively, I wouldn't be able to continue to also have significant others and a wide range of other things. And I wasn't special. A number of people, including the people I was doing cocaine with, also behaved the same way.

We need to continuously put pressure on politicians to do more, because they are happy just to do nothing—it’s easier to do nothing.

Our ability to study the brain has been limited because of our tools and our tools have only allowed us to look at one neurotransmitter and we haven't looked so much into co-localization and co-release of transmitters. Our thinking is hampered by our tools.

High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society.

One of the things that has happened is that our drug laws have been institutionalized now. If you want to say that somebody's a bad person in a movie or in a television show or something about that, you say they sell drugs or they use drugs.