Crack in the early 1980s or mid 1980s I'm sorry is that one of the worst myth is that one hit and you're addicted for life. We saw that in 1980s and we're seeing it again with methamphetamine today, one hit and you're addicted and it simply not true, addiction requires work not the people should go out and experiment or do these themselves but the fact is that's a myth and the concern is that, it's dangerous because when people perpetuates that myths and then when young people are people actually try methamphetamine or crack cocaine and find that, that doesn't happen to them.

Dopamine makes up less than one percent of the brain's neurotransmitters. It's a small portion. Dopamine is released when people are happy, angry, stressed. So it's really hard to call this specific neurotransmitter "the pleasure neurotransmitter."

One of the things that has happened is that our drug laws have been institutionalized now. If you want to say that somebody's a bad person in a movie or in a television show or something about that, you say they sell drugs or they use drugs.

I am glad that people are trying to have a rational conversation about drugs.

If you're a member of a despised group, look out! They'll find a drug and associate you with its use. There are a lot of people in the gay community using methamphetamine and paying taxes and going to work and doing well.

The way we're currently educating people about heroin is to say that heroin is so awful. Heroin is not so much the problem. It's when you combine it. It's hard to die from heroin alone.

Much of the early work focused on dopamine and we were really looking for rewarding sorts of effects and sure enough, we only found that. But you can destroy the main dopamine-producing structures of the brain and you can still get an animal to self-administer drugs like cocaine.