I think about my cocaine use. I liked it. I thought it was a great drug. But I knew that if I was doing that almost exclusively, I wouldn't be able to continue to also have significant others and a wide range of other things. And I wasn't special. A number of people, including the people I was doing cocaine with, also behaved the same way.

Dopamine makes up less than one percent of the brain's neurotransmitters. It's a small portion. Dopamine is released when people are happy, angry, stressed. So it's really hard to call this specific neurotransmitter "the pleasure neurotransmitter."

If you're a member of a despised group, look out! They'll find a drug and associate you with its use. There are a lot of people in the gay community using methamphetamine and paying taxes and going to work and doing well.

Writing in a nuanced way, getting at all the details in a way that remains interesting for the reader, is very difficult.

I've had investigations of my lab because people didn't like what I had to say. And when you have investigations and you're doing research, you're shut down for a while. You have to start all over again. So that's one area where I paid a high price.

Looking at the data and at my drug use and evaluating it carefully just let me see that I wasn't special, but my drug use challenged what I thought about cocaine. Because I would accept when I would say, "What happened to that person?" and someone would say, "They started using cocaine...they went downhill..." I would just accept that, even though I had a different experience and all these other people had a different experience. But I would throw that out because I thought my experience was an aberration.

Our ability to study the brain has been limited because of our tools and our tools have only allowed us to look at one neurotransmitter and we haven't looked so much into co-localization and co-release of transmitters. Our thinking is hampered by our tools.