Looking at the data and at my drug use and evaluating it carefully just let me see that I wasn't special, but my drug use challenged what I thought about cocaine. Because I would accept when I would say, "What happened to that person?" and someone would say, "They started using cocaine...they went downhill..." I would just accept that, even though I had a different experience and all these other people had a different experience. But I would throw that out because I thought my experience was an aberration.

Dopamine makes up less than one percent of the brain's neurotransmitters. It's a small portion. Dopamine is released when people are happy, angry, stressed. So it's really hard to call this specific neurotransmitter "the pleasure neurotransmitter."

The policy that received more attention particularly in the past decade and a half or so has been the US cocaine policy, the differential treatment of crack versus powder cocaine and question is how my research impacted my view on policy. Clearly that policy is not based on the weight of the scientific evidence. That is when the policy was implemented, the concern about crack cocaine was so great that something had to be done and congress acted in the only way they knew how, they passed policy and that's what a responsible society should do.

High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society.

The way we're currently educating people about heroin is to say that heroin is so awful. Heroin is not so much the problem. It's when you combine it. It's hard to die from heroin alone.

I don't want to be on the bandwagon of dogging any president or anybody in positions where they have all these different constituencies.

Much of the early work focused on dopamine and we were really looking for rewarding sorts of effects and sure enough, we only found that. But you can destroy the main dopamine-producing structures of the brain and you can still get an animal to self-administer drugs like cocaine.