Extinction is the rule. Survival is the exception.

Ask courageous questions. Do not be satisfied with superficial answers.

The universe seems neither benign nor hostile, merely indifferent.

When you look more generally at life on Earth, you find that it is all the same kind of life. There are not many different kinds; there's only one kind. It uses about fifty fundamental biological building blocks, organic molecules.

If you want to make a [rhubarb] pie from scratch, first you have to create the universe.

The truth may be puzzling. It may take some work to grapple with. It may be counterintuitive. It may contradict deeply held prejudices. It may not be consonant with what we desperately want to be true. But our preferences do not determine what's true.

There is no other species on Earth that does science. It is, so far, entirely a human invention, evolved by natural selection in the cerebral cortex for one simple reason: it works. It is not perfect. It can be misused. It is only a tool. But it is by far the best tool we have, self-correcting, ongoing, applicable to everything.