There is not a single truth of science upon which we ought to bet more than about a million of millions to one.

Truly, that reason upon which we plume ourselves, though it may answer for little things, yet for great decisions is hardly surer than a toss up.

A sign, or representamen, is something which stands to somebody for something in some respect or capacity. It addresses somebody,that is, creates in the mind of that person an equivalent sign, or perhaps a more developed sign. That sign which it creates I call the interpretant of the first sign. The sign stands for something, its object. It stands for that object, not in all respects, but in reference to a sort of idea, which I have sometimes called the ground of the representamen.

In all the works on pedagogy that ever I read — and they have been many, big, and heavy — I don't remember that any one has advocated a system of teaching by practical jokes, mostly cruel. That, however, describes the method of our great teacher, Experience.

And what, then, is belief? It is the demi-cadence which closes a musical phrase in the symphony of our intellectual life.

It is not too much to say that next after the passion to learn there is no quality so indispensable to the successful prosecutionof science as imagination. Find me a people whose early medicine is not mixed up with magic and incantations, and I will find you a people devoid of all scientific ability.

We cannot begin with complete doubt.