If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
Charles Scott SherringtonThe brain is a mystery; it has been and still will be. How does the brain produce thoughts? That is the central question and we have still no answer to it.
Charles Scott SherringtonSwiftly the head mass becomes an enchanted loom where millions of flashing shuttles weave a dissolving pattern, always a meaningful pattern though never an abiding one...
Charles Scott SherringtonFurther study of central nervous action, however, finds central inhibition too extensive and ubiquitous to make it likely that it is confined solely to the taxis of antagonistic muscles.
Charles Scott Sherrington