Decide in your heart of hearts what really excites and challenges you, and start moving your life in that direction. Every decision you make, from what you eat to what you do with your time tonight, turns you into who you are tomorrow, and the day after that. Look at who you want to be, and start sculpting yourself into that person. You may not get exactly where you thought you'd be, but you will be doing things that suit you in a profession you believe in. Don't let life randomly kick you into the adult you don't want to become.

Almost everything worthwhile carries with it some sort of risk, whether it's starting a new business, whether it's leaving home, whether it's getting married, or whether it's flying in space.

Scientific literacy is one of the underpinnings of everything I do. It's why I work with schools. It's why I teach at university. I do a lot of outreach to try and improve general scientific literacy, but the core of all scientific literacy is just literacy.

By looking at the difference between perceived danger and actual danger, you can fundamentally change your reaction.

Sweat the small stuff. Without letting anyone see you sweat.

My optimism and confidence come not from feeling I'm luckier than other mortals, and they sure don't come from visualizing victory. They're the result of a lifetime spent visualizing defeat and figuring out how to prevent it. Like most astronauts, I'm pretty sure that I can deal with what life throws at me because I've thought about what to do if things go wrong, as well as right. That's the power of negative thinking.

Our role is to develop techniques that allow us to provide emergency life-saving procedures to injured patients in an extreme, remote environment without the presence of a physician.