If you haven't learned to ride a bike by the time your peer group has, then suddenly it's an embarrassment and you'll avoid opportunities where you're expected to ride a bike. And then it starts shaping your behaviour. Reading is much subtler, but much more destructive if you have not - for whatever reason - learned to read by the time you should.

Decide in your heart of hearts what really excites and challenges you, and start moving your life in that direction. Every decision you make, from what you eat to what you do with your time tonight, turns you into who you are tomorrow, and the day after that. Look at who you want to be, and start sculpting yourself into that person. You may not get exactly where you thought you'd be, but you will be doing things that suit you in a profession you believe in. Don't let life randomly kick you into the adult you don't want to become.

I want to know: How does a space suit on Mars work? Show me how it is pressurized, and how it is cooled. What's the glove design? None of that stuff can be bought off the rack. It does not exist. You can't just go to SpaceMart and buy those things.

Almost everything worthwhile carries with it some sort of risk.

The rough and ready improvisational quality to life on board the International Space Station is reminiscent of a long trip in a sailboat: privacy and fresh produce are in short supply, hygiene is basic, and a fair amount of the crew's time is spent just on maintaining and repairing the craft.

In my experience, fear comes from not knowing what to expect and not feeling you have any control over what’s about to happen. When you feel helpless, you’re far more afraid than you would be if you knew the facts.

My optimism and confidence come not from feeling I'm luckier than other mortals, and they sure don't come from visualizing victory. They're the result of a lifetime spent visualizing defeat and figuring out how to prevent it. Like most astronauts, I'm pretty sure that I can deal with what life throws at me because I've thought about what to do if things go wrong, as well as right. That's the power of negative thinking.