So far, I have decided to take whatever my disease can throw at me, and to stay combative even while taking the measure of my inevitable decline. I repeat, this is no more than what a healthy person has to do in slower motion.

A rule of thumb with humor; if you worry that you might be going too far, you have already not gone far enough. If everybody laughs, you have failed.

The thing about religion is that it's the first and the worst. The worst because it's the first.

Skepticism rather than credulity is the highest principle that the human intellect can use to ennoble our existence.

In the grip of a neurological disorder, I am fast losing control of words even as my relationship with the world has been reduced to them.

For most of my life I let women do the driving and was happy to let them.

Never ask while you are doing it if what you are doing is fun. Don't introduce even your most reliably witty acquaintance as someone who will set the table on a roar.