Mediocre men often have the most acquired knowledge. It is in the darker. It is in the darker regions of science that great men are recognized; they are marked by ideas which light up phenomena hitherto obscure and carry science forward.

Ardent desire for knowledge, in fact, is the one motive attracting and supporting investigators in their efforts; and just this knowledge, really grasped and yet always flying before them, becomes at once their sole torment and their sole happiness. Those who do not know the torment of the unknown cannot have the joy of discovery which is certainly the liveliest that the mind of man can ever feel.

When we meet a fact which contradicts a prevailing theory, we must accept the fact and abandon the theory, even when the theory is supported by great names and generally accepted.

I do not ... reject the use of statistics in medicine, but I condemn not trying to get beyond them and believing in statistics as the foundation of medical science. ... Statistics ... apply only to cases in which the cause of the facts observed is still [uncertain or] indeterminate. ... There will always be some indeterminism ... in all the sciences, and more in medicine than in any other. But man's intellectual conquest consists in lessening and driving back indeterminism in proportion as he gains ground for determinism by the help of the experimental method.

A discovery is generally an unforeseen relation not included in theory.

The physiologist is not a man of the world, he is a scientist, a man caught and absorbed by a scientific idea that he pursues; he no longer hears the cries of the animals, no longer sees the flowing blood, he sees only his idea: organisms that hide from him problems that he wants to discover. He doesn't feel that he is in a horrible carnage; under the influence of a scientific idea, he pursues with delight a nervous filament inside stinking and livid flesh that for any other person would be an object of disgust and horror.

The science of life is a superb and dazzlingly lighted hall which may be reached only by passing through a long and ghastly kitchen.