Mediocre men often have the most acquired knowledge. It is in the darker. It is in the darker regions of science that great men are recognized; they are marked by ideas which light up phenomena hitherto obscure and carry science forward.

As soon as the circumstances of an experiment are well known, we stop gathering statistics. ... The effect will occur always without exception, because the cause of the phenomena is accurately defined. Only when a phenomenon includes conditions as yet undefined,Only when a phenomenon includes conditions as yet undefined, can we compile statistics. ... we must learn therefore that we compile statistics only when we cannot possibly help it; for in my opinion, statistics can never yield scientific truth.

Men who have excessive faith in their theories or ideas are not only ill prepared for making discoveries; they also make very poor observations. Of necessity, they observe with a preconceived idea, and when they devise an experiment, they can see, in its results,only a confirmation of their theory. In this way they distort observation and often neglect very important facts because they do not further their aim.

[Those] who have an excessive faith in their theories or in their ideas are not only poorly disposed to make discoveries, but they also make very poor observations.

We must alter theory to adapt it to nature, but not nature to adapt it to theory.‎

Man does not limit himself to seeing; he thinks and insists on learning the meaning of phenomena whose existence has been revealed to him by observation. So he reasons, compares facts, puts questions to them, and by the answers which he extracts, tests one by another. This sort of control, by means of reasoning and facts, is what constitutes experiment, properly speaking; and it is the only process that we have for teaching ourselves about the nature of things outside us.

Ardent desire for knowledge, in fact, is the one motive attracting and supporting investigators in their efforts; and just this knowledge, really grasped and yet always flying before them, becomes at once their sole torment and their sole happiness. Those who do not know the torment of the unknown cannot have the joy of discovery which is certainly the liveliest that the mind of man can ever feel.