I'm as fond of my body as anyone, but if I can be 200 with a body of silicon, I'll take it.

Your genome knows much more about your medical history than you do.

If you hear an expert talking about the Internet and saying it [does] this, or it will do that, you should treat it with the same skepticism that you might treat the comments of an economist about the economy or a weatherman about the weather.

What we need is a plan B ... independent of the Internet. [It] doesn't necessarily have to have the performance of the Internet, but the police department has to be able to call up the fire department.

The computers are in control. We just live in their world.

A novice was trying to fix a broken Lisp machine by turning the power off and on. Knight, seeing what the student was doing, spoke sternly: "You cannot fix a machine by just power-cycling it with no understanding of what is going wrong." Knight turned the machine off and on. The machine worked.

Technology is everything that doesn’t work yet.