There is just so much stuff in the world that, to me, is devoid of any real substance, value, and content that I just try to make sure that I am working on things that matter.

I think in our lifetime, that level of acceptance of "well, we couldn't do any better," won't be tolerated. We're going to start to see individual therapies customized for individual patients, and it's going to change the way people get healthcare.

[Chuck's wife] was standing behind me at the time and she said, 'Chuck hasn't fed himself in 19 years. So, you've got a choice: We keep the arm, or you keep Chuck.'

Inspiration comes from the heart. The letter ‘I’ is the heart of F”I”RST… (F Inspiration R S T).

People take the longest possible paths, digress to numerous dead ends, and make all kinds of mistakes. Then historians come along and write summaries of this messy, nonlinear process and make it appear like a simple, straight line.

I do not want to waste any time. And if you are not working on important things, you are wasting time.

What really makes it an invention is that someone decides not to change the solution to a known problem, but to change the question.