So much goes into doing a transplant operation. All the way from preparing the patient, to procuring the donor. It's like being an astronaut. The astronaut gets all the credit, he gets the trip to the moon, but he had nothing to do with the creation of the rocket, or navigating the ship. He's the privileged one who gets to drive to the moon. I feel that way in some of these more difficult operations, like the heart transplant.

Of the many 'firsts' with which I have been involved at the Texas Heart Institute —including the first successful human heart transplant in the United States and the first total artificial heart transplant in the world—the achievement that may have the greatest impact on health care did not occur in the operating room or in the research laboratory. It happened on a piece of paper... when we created the first-ever packaged pricing plan for cardiovascular surgical procedures.

The man who inspired me most, I think, was Dr. Alfred Blalock, who was professor of surgery at Johns Hopkins. He was a rather simple man with a burning curiosity. It was through his curiosity that he made many real contributions to medical science.

A successful surgeon should be a man who, when asked to name the three best surgeons in the world, would have difficulty deciding on the other two.

[The heart is] really a fascinating organ. It's about the only organ in the body that you can really witness its function. Doing things. And so on. Some of the other organs you can witness, like the intestines, will have this sort of peristaltic motion. But nothing that can compare with the activity of the human heart.

I find I'm luckier when I work harder.

I think work is a privilege. ... It keeps you alive, spiritually.