I find I'm luckier when I work harder.

[The heart is] really a fascinating organ. It's about the only organ in the body that you can really witness its function. Doing things. And so on. Some of the other organs you can witness, like the intestines, will have this sort of peristaltic motion. But nothing that can compare with the activity of the human heart.

I still take failure very seriously, but I've found that the only way I could overcome the feeling is to keep on working, and trying to benefit from failures or disappointments. There are always some lessons to be learned. So I keep on working.

Of the many 'firsts' with which I have been involved at the Texas Heart Institute —including the first successful human heart transplant in the United States and the first total artificial heart transplant in the world—the achievement that may have the greatest impact on health care did not occur in the operating room or in the research laboratory. It happened on a piece of paper... when we created the first-ever packaged pricing plan for cardiovascular surgical procedures.

I've always felt that maybe one of the reasons that I did well as a student and made such good grades was because I lacked confidence. Lacked self-confidence, and I never felt that I was prepared to take an examination, and I had to study a little bit extra. So that sort of lack of confidence helped me, I think, to make a good record when I was a student.

I find I'm luckier when I work harder.

A successful surgeon should be a man who, when asked to name the three best surgeons in the world, would have difficulty deciding on the other two.