I have accomplished a lot, but it didn't happen overnight for me. I was 35 when I got the show, and had been working professionally for 15 years. It would be a lot weirder if I were in my early 20s and stumbled into it.

I'd never been to Africa. This really was my first film [The Lost World]. I'd done 10 years of stage. I'd done a little bit of television. But this was my first film.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

There wasn't an episode of 'Will & Grace' that didn't begin with my voice saying, 'Will & Grace' is taped before a live studio audience.

I had a couple of decent laughs on Townies, but for the most part, delivering a joke that you just know is not funny is hard.

[Jack Nash from The Andromeda Strain] was not in the original film, but he was kind of a Geraldo Rivera almost kind of reporter that had a drug addiction. We start the story in rehab, and then he gets the roots of the story. I loved him.

I love playing anyone that does stuff that I don't do. The fun of playing an assassin is that I've never killed anybody. The fun of playing a brilliant musician is that I don't actually play any instruments.