The thing you realize pretty quickly, though, is that being in front of an audience whose job it is to laugh is a big pressure if the writing is not hilarious.

Brad Wright, who created Grant MacLaren, had me in mind. We'd actually worked together 20 years ago. He wrote an episode of The Outer Limits that I was in in '96 or '95? So we'd been aware of each other for years. I'd lived in Vancouver off and on, where he's based. And it just came to me, and I'm always looking for something different. Perception was a different show than Will & Grace.

That was my big break [Lonesome Dove]. My first real kind of adult role on something really well-written. It was a spin-off of the miniseries, and I played Col. Mosby, a very dangerous, Southern colonel in post-Civil War, wandering the West.

There wasn't an episode of 'Will & Grace' that didn't begin with my voice saying, 'Will & Grace' is taped before a live studio audience.

I jump out of the boat [in The Lost World], and I'm trying to swim to the kid, and my boots fill with water, and I start to drown, and the director has no idea why I'm flailing around. He's, "Come on, come on!" And I managed to rescue myself. I'm wet and sitting on the banks of the river, and John walks over to me and says, "Are you all right, dear boy?" "Yeah, I'm all right."

[Trust Me] was TNT, and they were really supportive of the show, but in the end they just didn't feel it was their audience. I never really understood why we didn't get a longer run at it, because it was Griffin Dunne and Monica Potter. Just a really strong cast.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.