I got Michael Caine's book, Acting In Film, and I read it on the plane, desperately trying to glean information from him about how to adapt my craft, which was actually very helpful.

The three main leads [in Townies] were Lauren [ Graham] and Jenna [Elfman] and Molly [Ringwald], and then Ron Livingston was on it as well. There was a lot of people to write funny stuff for.

There was not an episode [on Perception] that didn't deal with some form of mental illness, either my own, or I would be the first to notice if a defendant did a certain thing that perhaps he was suffering from this. And so we got to do some really outspoken stuff for what was otherwise a crime-solving show. And it was just a really good team.

I like playing a character every day. I like having something to go back to. I always enjoyed that with 'Will & Grace.' I like the camaraderie. I like having a crew that I know and I can work with every day.

Often, particularly with voices, you're hearing horrible things, demon voices, and voices telling them that they're not worth it or that they're going to kill somebody. In those moments, they're overcoming things.

That was my big break [Lonesome Dove]. My first real kind of adult role on something really well-written. It was a spin-off of the miniseries, and I played Col. Mosby, a very dangerous, Southern colonel in post-Civil War, wandering the West.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.