When we started the show [Lonesome Dove], Suzanne De Passe - who had done the original miniseries and still owned the property and was turning it into this series - she brought in a lot of old friends - Diahann Carroll and Billy Dee Williams and Dennis Weaver. And we had an interesting collection off the top of these old seasoned actors. Billy Dee was lovely and iconic.

Rachael Leigh Cook was my leading lady. She was awesome. We loved the show [Perception ]. Again, it was more of a TNT show, because there were crimes that got solved, which [going] back five years ago, was a mandate. But there was something innovative about the mental illness side of it.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

They're such different things [Townies and Lonesome Dove]. I certainly love them both. Certainly Lonesome Dove would be way hard now, because, I mean, back then I wasn't married.

I think I was very lucky that I didn't get well-known until my early thirties. If it had happened when I was younger, you might have seen me falling out of nightclubs. I think I conducted myself as a much better human being because I was already married when all that came along (I got married five months after I got the role as Will).

Every actor has periods of their life that are a little less busy than others, and that was just a time when I needed that. And to be back on a sitcom stage, with Julia [ Louis-Dreyfus], was really, really fun.

I'm doing a very funny show in which we talk about issues. I speak at Aids charities and things. It's great to do something fun with our days and yet we're told we're doing something important.