Never say, "I tried it once and it did not work."

Splitting the atom is like trying to shoot a gnat in the Albert Hall at night and using ten million rounds of ammunition on the off chance of getting it. That should convince you that the atom will always be a sink of energy and never a reservoir of energy.

Every good laboratory consists of first rate men working in great harmony to insure the progress of science; but down at the end of the hall is an unsociable, wrong-headed fellow working on unprofitable lines, and in his hands lies the hope of discovery.

An alleged scientific discovery has no merit unless it can be explained to a barmaid.

When we have found how the nucleus of atoms is built up we shall have found the greatest secret of all — except life. We shall have found the basis of everything — of the earth we walk on, of the air we breathe, of the sunshine, of our physical body itself, of everything in the world, however great or however small — except life.

I congratulate you both on a fine piece of work which I am sure will ultimately prove of importance. I am personally very much interested in your results... In the past I have tried a number of experiments... but without any success.

Should a young scientist working with me come to me after two years of such work and ask me what to do next, I would advise him to get out of science. After two years of work, if a man does not know what to do next, he will never make a real scientist.