People come into public life for different reasons. None of us are ego-challenged, I think, or we probably wouldn't be doing what we're doing, so if anyone tells you that they don't like the sound of the applause and the ego gratification, I don't think they're being straight with you.

In recent years, we have seen technology advance at lightning speed, allowing us to accomplish lifesaving feats never imagined before. It is our responsibility to ensure that these advances are used for positive medical breakthroughs, and not allowed to restrict rights or limit access to health insurance or job opportunities.

Filibusters have proliferated because under current rules just one or two determined senators can stop the Senate from functioning. Today, the mere threat of a filibuster is enough to stop a vote; senators are rarely asked to pull all-nighters like Jimmy Stewart in 'Mr. Smith Goes to Washington.'

If I could create one job in the private sector by helping to grow a business, that would be one more than Congress has created in the last six months.

Filibusters should require 35 senators to... make a commitment to continually debate an issue in reality, not just in theory. The number of votes needed to overcome a filibuster should be reduced to 55 from 60.

If one of my boys was asking me if they should go into politics, I'd say there's only one reason to go into public life and that's to help people.

You now have six-year campaigns for the Senate - you never stop running. It's not uncommon for a member of the Senate to have a fundraising breakfast, a fundraising lunch and a fundraising dinner, and then when the Senate breaks for the week to go home, more fundraisers. And that's driven by the cost of campaigning.