Failure of your company is not failure in life. Failure in your relationships is.

Hard things are valuable; easy things are not so valuable. Reaching the mountaintop is rewarding because it is hard. If it was easy, everybody would do it.

Every major communication tool on the Internet has spam and abuse problems. All email services, blogging services and social networks have to dedicate a significant amount of resources and time to fighting abuse and protecting their users.

Take care of yourself: When you don't sleep, eat crap, don't exercise, and are living off adrenaline for too long, your performance suffers. Your decisions suffer. Your company suffers. Love those close to you: Failure of your company is not failure in life. Failure in your relationship is.

When I meet with the founders of a new company, my advice is almost always, ‘Do fewer things.’ It’s true of partnerships, marketing opportunities, anything that’s taking up your time. The vast majority of things are distractions, and very few really matter to your success.

I tried to be a ski bum when I stepped away from Twitter, and I wasn't a very good skier.

I suspect there's a lot of validity to the premise that big companies aren't going to attract entrepreneurial talent.