Again the message to experimentalists is: Be sensible but don't be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
Francis CrickFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Francis CrickMoreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
Francis CrickThere is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
Francis CrickWhat could be more foolish than to base one's entire view of life on ideas that, however plausible at the time, now appear to be quite erroneous? And what would be more important than to find our true place in the universe by removing one by one these unfortunate vestiges of earlier beliefs?
Francis Crick