Life cannot have had a random beginning. ... The trouble is that there are about two thousand enzymes, and the chance of obtaining them all in a random trial is only one part in 10 to the 40,000 power, an outrageously small probability that could not be faced even if the whole universe consisted of organic soup.

I am genuinely sorry for scientists of the younger generation who never knew Fisher personally. So long as you avoided a handful of subjects like inverse probability that would turn Fisher in the briefest possible moment from extreme urbanity into a boiling cauldron of wrath, you got by with little worse than a thick head from the port which he, like the Cambridge mathematician J. E. Littlewood, loved to drink in the evening. And on the credit side you gained a cherished memory of English spoken in a Shakespearean style and delivered in the manner of a Spanish grandee.

Once we see, however, that the probability of life originating at random is so utterly minuscule as to make it absurd, it becomes sensible to think that the favorable properties of physics, on which life depends, are in every respect deliberate.... It is, therefore, almost inevitable that our own measure of intelligence must reflect higher intelligence -even to the limit of God.

In short there is not a shred of objective evidence to support the hypothesis that life began in an organic soup here on the Earth.

The man who voyages strange seas must of necessity be a little unsure of himself. It is the man with the flashy air of knowing everything, who is always with it, that we should beware of.

Imagine 1050 blind persons each with a scrambled Rubik's cube, and try to conceive of the chance of them all simultaneously arriving at the solved form. You then have a chance of arriving by random shuffling, of just one of the many biopolymers on which life depends. The notion that not only the biopolymers but the operating program of a living cell could be arrived at by chance in a primordial organic soup here on the Earth is evidently nonsense of a high order.

Earlier theories ... were based on the hypothesis that all the matter in the universe was created in one big bang at a particular time in the remote past. [Coining the "big bang" expression.]