A DNA sequence for the genome of bacteriophage ฮฆX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
Frederick SangerInitially I had intended to study medicine, but before going to University I had decided that I would be better suited to a career in which I could concentrate my activities and interests more on a single goal than appeared to be possible in my father's profession.
Frederick SangerIt is like a voyage of discovery into unknown lands, seeking not for new territory but for new knowledge. It should appeal to those with a good sense of adventure.
Frederick Sanger