I have no idea how it got so big. I was just trying to find something to do while I was living in Boulder, Colorado, which isn't really a funny town. There are a lot of smart people there, but comedy isn't at the forefront of their minds.

There's a built-up tension in religion, and if you can release it, you'll get a huge and satisfying laugh.

I don't like that The Simpsons are spokespeople for Burger King and MasterCard and Butterfinger. In the first Gulf War, I was really upset that the Simpsons characters were being drawn on tanks and bombs. But those are things that I don't control.

The people who seem to have a lock on power get swept out in a couple of years. So it's naïve to keep swinging at the same targets over and over. It took me a long time to realize, but most of the shackles that I flailed against were just illusory.

I find that the creative side of my brain and the archival side of my brain don't work well together. When I've done my best work, I've been in a trance-like state.

If there's reason for hope, it lies in man's occasional binges of cooperation. To save our planet, we'll need that kind of heroic effort, in which all types of people join forces for the common good

As a John Kerry supporter, I wanted to send him a check. But then it occurred to me that most of that money would end up in the hands of advertising agencies and television networks. And the money would be used to create deceptive commercials that flatter our point of view and shade the facts our way. And I wasn't comfortable with that. But on the other hand, that's how the game is played. You're always grappling.