Most theoretical work since the proposals of Hebb (1949) and Hayek (1952) has relied upon particular forms of dependent synaptic rules in which either pre- or postsynaptic change is contingent upon closely occurring events in both neurons taking part in the synapse.
Gerald EdelmanHebb place the Law of Effect at the synaptic level by proposing a correlation model of synaptic modification similar to that of Hayek (1952). This work was seminal in providing a basis for many subsequent theoretical studies . .
Gerald EdelmanYour brain develops depending on your individual history. What has gone on in your own brain and its consciousness over your lifetime is not repeatable, ever - not with identical twins, not even with conjoined twins.
Gerald EdelmanWe're inquiring into the deepest nature of our constitutions: How we inherit from each other. How we can change. How our minds think. How our will is related to our thoughts. How our thoughts are related to our molecules.
Gerald EdelmanHayek made a quite fruitful suggestion, made contemporaneously by the psychologist Donald Hebb, that whatever kind of encounter the sensory system has with the world, a corresponding event between a particular cell in the brain and some other cell carrying the information from the outside word must result in reinforcement of the connection between those cells. These day, this is known as a Hebbian synapse, but von Hayek quite independently came upon the idea. I think the essence of his analysis still remains with us.
Gerald Edelman