Most theoretical work since the proposals of Hebb (1949) and Hayek (1952) has relied upon particular forms of dependent synaptic rules in which either pre- or postsynaptic change is contingent upon closely occurring events in both neurons taking part in the synapse.
Gerald EdelmanSince the idea that modification of synaptic function can provide a basis for memory arose shortly after the first anatomical description of the synapse a number of models (Hebb 1949 . . Hayek 1952 . . Kendel 1981) have been proposed in which various cognitive activities are represented by combinations of the firing patterns of individual neurons.
Gerald EdelmanWe're inquiring into the deepest nature of our constitutions: How we inherit from each other. How we can change. How our minds think. How our will is related to our thoughts. How our thoughts are related to our molecules.
Gerald Edelman